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Mesothelioma Risk Factors

Mesothelioma risk factors may increase a person’s chance of developing this deadly cancer. Asbestos exposure is the only known cause of malignant (cancerous) mesothelioma, but not everyone exposed to asbestos develops the disease. Certain risk factors — such as asbestos exposure levels, age, and genetics — may increase the risk of developing this cancer.

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Mesothelioma Risk Factors Explained

A risk factor is anything that increases an individual’s chance of getting a disease. Some malignant mesothelioma risk factors are beyond a person’s control.

Uncontrolled mesothelioma risk factors include:

  • Age
  • Gender
  • Genes

These risk factors are important to recognize because they can help mesothelioma victims and their doctors identify and diagnose mesothelioma at earlier stages when it is easier to treat.

Other risk factors may be preventable.

Preventable mesothelioma risk factors include:

  • Diet
  • Cigarette and alcohol consumption
  • Other health-related choices

Individuals can make life choices to avoid these risk factors and reduce their chances of developing mesothelioma or other similar cancers.

However, the single largest risk factor for mesothelioma is exposure to asbestos — a danger that millions of Americans were unknowingly exposed to by asbestos-containing product manufacturers.

Asbestos Exposure as a Mesothelioma Risk Factor

According to the National Organization of Rare Diseases (NORD), asbestos exposure is “the major associated risk factor for mesothelioma.”

Asbestos is a naturally occurring mineral that develops as a fibrous bundle. It forms in rocks and deposits throughout the world, and its flexibility, durability, and resistance to fire made asbestos a popular material for a wide range of products throughout the 20th century and even today.

Occupational Exposure Risks

Many American blue-collar workers faced an increased risk of exposure to asbestos on a daily basis, especially at the height of its use in the 20th century.

Occupations with high asbestos exposure risk include:

  • Construction Workers: A huge number of construction materials were once made with asbestos. Construction workers, from drywall installers to tile setters to roofers and painters, likely handled asbestos on a daily basis as late as the 1990s.
  • Firefighters: Older buildings often contain a lot of asbestos-containing materials, so when these buildings catch fire, dangerous asbestos particles are released into the air. Unfortunately, firefighters are often exposed to this asbestos dust while saving lives.
  • Insulators: Insulators often needed to install or remove asbestos-based insulation from buildings. This close contact with disturbed asbestos fibers put them at higher than average risk of inhaling or ingesting asbestos particles.
  • Plumbers: Pipes were once commonly wrapped in asbestos for insulation. Plumbers, pipelayers, pipefitters, and steamfitters often removed this insulation as part of their job, leading to high rates of asbestos-related diseases.
  • Shipbuilders: Both military personnel and civilians building ships in shipyards were at incredibly high risk of asbestos exposure, as the mineral was a popular insulation and fireproofing material on ships.

Many other individuals who do not fall into these groups are at higher risk of developing mesothelioma through occupational asbestos exposure.

Military Asbestos Exposure Risks

Sadly, United States veterans are at especially high risk for mesothelioma because of the military’s heavy use of the mineral from around 1935-1975.

While its flame-resistant properties and high durability helped protect military personnel, it also caused great harm. According to a medical study published in the journal Ultrastructural Pathology, veterans represent roughly a third of those diagnosed with mesothelioma.

Veterans may have been exposed to asbestos in:

  • Aircraft
  • Navy ships
  • Military bases and living quarters
  • Shipyards
  • Vehicles

While the U.S. military took great efforts to remove asbestos from their ships and other assets once its dangers became known, millions of veterans and their family members may have been exposed.

Our free Mesothelioma Justice Guide has detailed information about where victims may have been exposed to asbestos.

Asbestos Exposure Risk at Home

Asbestos is best known for its use in insulation, but it can also be found in roofing, machinery, and a wide range of industrial applications.

Since the Industrial Revolution, the use of asbestos was common in these materials to create buildings — including homes. According to the American Cancer Society (ACS), since the mid-1970s, the United States dramatically decreased the amount of asbestos use in the country. However, many older homes still contain asbestos.

If undisturbed, asbestos in building materials should not cause harm. However, activities such as drilling and remodeling or natural wear and tear to a home may loosen fibers, causing them to be inhaled or ingested.

Individuals living in older homes may benefit from having a trained asbestos abatement professional test their home for asbestos fibers. They should never attempt to remove asbestos on their own.

Environmental Asbestos Exposure

While it is rare, some people may be exposed to asbestos in the natural environment.

Naturally-occurring asbestos deposits may be exposed through asbestos mining, putting individuals who live near the asbestos mine at risk when the mineral is disturbed and released into the air or brought home on clothing.

One example of environmental asbestos exposure was man-made. Since 1919, the residents of Libby, Montana, were poisoned by toxic asbestos dust from the vermiculite mines established there.

As reported by The Guardian, “the rate of lung disease in Libby is between 40 and 60 times the national average.”

While many cases of mesothelioma develop in miners and their immediate family members, many others occur in individuals merely living near areas where asbestos mining took place.

Asbestos Exposure Levels and Risk

People at the greatest risk of developing mesothelioma seem to be those who have been exposed to high levels of asbestos for significant periods of time.

However, the Occupational Safety and Health Administration (OSHA), “there is no ‘safe’ level of asbestos exposure for any type of asbestos fiber.’

Anyone who has been exposed to asbestos is at risk of developing mesothelioma. This risk does not appear to decrease over time, and asbestos exposure remains a risk factor long after the exposure has stopped.

However, most people exposed to asbestos do not develop mesothelioma.

Other Substances as Mesothelioma Risk Factors

Researchers are studying a few other substances that may be mesothelioma risk factors. To date, asbestos is the only confirmed cause of mesothelioma, but a few studies have noted a potential link between other substances and the development of mesothelioma.

Zeolite and Erionite Exposure

Zeolites are a type of mineral with similar properties to asbestos. Some research has linked exposure to zeolite to the development of mesothelioma.

One zeolite found in Turkey and parts of the United States called erionite was extensively studied in the search for a “mesothelioma gene.” It was discovered that at least one genetic mutation resulted in mesothelioma within entire family groups when they were exposed to naturally occurring erionite.

Zeolites have strong purification and absorption properties that make them a popular choice for many commercial and household products.

Natural and artificially created zeolites may be used in:

  • Animal feed
  • Detergents
  • Pet litter
  • Purification applications

The United States Geological Survey currently recognizes approximately 40 naturally occurring zeolites, which can be found in rocks and ashes, and an additional 150 synthesized zeolites.

However, it is unknown how many, if any, of these substances present risk factors for mesothelioma.

Carbon Nanotubes

Carbon nanotubes have not been proven to be a mesothelioma risk factor, but they are under scrutiny because of their similarities to asbestos.

Carbon nanotubes are microscopic nanoparticles shaped like tubes. They are used in nanotechnology, optics, and electronics because of their excellent electrical conductivity.

Radiation Therapy

Radiation therapy used in the course of cancer treatment — or in occupational settings, such as by radiology technicians — has been linked to the development of mesothelioma.

It is believed that the same radiation that kills cancer cells may sometimes cause healthy cells to develop mutations that, in rare cases, lead to mesothelioma.

Other forms of radiation have also been linked to mesothelioma, including ongoing low-grade exposure to atomic radiation energy.

Individuals may also be at risk of developing mesothelioma if they received the radioactive drug Thorotrast, which was used for X-rays until its dangerous side effects were discovered in the 1950s.

According to a study published in the International Journal of Cancer, elevated risks for lung carcinoma and malignant mesothelioma were identified in patients who were injected with this drug.

SV40 Virus

Individuals who received a certain polio vaccination and were also exposed to asbestos may be at an increased risk of developing mesothelioma due to a virus known as simian virus 40 (SV40). Those who contracted the virus after it was introduced in humans may also be at increased risk.

While polio vaccines are considered safe by the Centers for Disease Control and Prevention (CDC), an outbreak of SV40 in monkeys accidentally made it into millions of vaccinations between 1955-1963.

SV40 is a virus that alters the genetic composition of cells, potentially leading to mutations that, along with asbestos fibers, cause mesothelioma.

Studies such as one published in the journal Cancer Research are not conclusive, but there is enough evidence to warrant caution in individuals known to have been exposed to the SV40 virus.

Lifestyle & Other Risk Factors

While limited research has been done on lifestyle risk factors for mesothelioma specifically, there has been an abundance of research into how lifestyle impacts cancer risk in general.

The World Cancer Fund estimates that 20% of all cancer is preventable and may be eliminated through healthy lifestyle choices such as avoiding certain foods and getting enough exercise.

It is important to note that these lifestyle risk factors alone do not contribute to mesothelioma and there is no evidence that they lower a person’s risk of developing mesothelioma after being exposed to asbestos.

However, lifestyle risk factors may put asbestos-exposed people at greater risk of developing mesothelioma after their exposure.

Poor Nutrition

Cancer researchers have noted that people who do not smoke and eat at least five servings of fruits and vegetables each day have a lower risk of developing lung cancer.

Maintaining a healthy weight through diet and regular exercise is one of the best ways to control this risk factor and minimize the likelihood of developing mesothelioma.

Alcohol Consumption

The ACS recommends that men drink a maximum of 2 alcoholic beverages per day, while women should only drink a maximum of 1 alcoholic beverage.

One beverage is considered 12 ounces of beer, 1.5 ounces of 80-proof hard liquor, or 5 ounces of wine. Drinking more than this amount on a regular basis may be a risk factor for developing cancer.

Smoking

Smoking does not cause mesothelioma, but asbestos-exposed individuals who also smoke are twice as likely to develop the disease.

This may be because smoking causes significant independent damage to the lungs. Smoking is, therefore, considered a mesothelioma risk factor.

In addition, researchers have found a potential link between smoking and the BAP1 gene mutation that increases the likelihood of developing mesothelioma.

The Mesothelioma Justice Network team is available 24/7 to answer your questions about mesothelioma risk factors.

Uncontrollable Risk Factors

Several mesothelioma risk factors are beyond an individual’s control, but it is important to be aware of them.

Having multiple mesothelioma risk factors makes it more likely that an individual will develop the deadly cancer. Therefore, being aware of even the uncontrollable risk factors can help diagnose mesothelioma at an early stage, which may significantly improve prognosis (disease outlook).

Genetics

Mesothelioma, like all cancers, is caused by genetic mutations that lead to uncontrolled cell growth. Some people are naturally predisposed to genetic mutations, carrying genes or other biological markers that make their cells more likely to mutate later in life.

One example is the BAP1 gene mutation, which has been identified in some families and has, according to the ACS, been linked to the development of mesothelioma, eye melanoma, and other cancers.

When this particular BAP1 mutation is combined with asbestos exposure, mesothelioma may be more likely to develop than it would in someone without the gene.

Age

Mesothelioma has been diagnosed in children and young adults. However, according to a 2017 study published in Lung Cancer International, roughly two-thirds of mesothelioma patients are age 65 or older, making age a risk factor for mesothelioma.

Tiny asbestos fibers irritate the cells of the organ linings where they are lodged, causing more genetic mutations over time.

Combined with the body’s natural tendency to create more mutations as it ages, asbestos-exposed individuals develop an increasingly higher risk of mesothelioma as they grow older.

Gender

Men are more likely to be diagnosed with mesothelioma, likely due to their increased exposure to asbestos compared to women. Men often work in jobs that put them in direct or indirect contact with asbestos, such as military work and construction.

However, when comparing male and female mesothelioma victims, some studies found that female mesothelioma victims tend to survive longer with the disease.

Women with mesothelioma may outlive male victims because they:

  • Are less likely to be exposed to asbestos and likely to have lower exposure levels
  • Are overrepresented among peritoneal mesothelioma victims, who have a longer median survival time than pleural mesothelioma victims
  • Tend to be diagnosed at a younger age than male victims
  • Have higher estrogen levels, which some studies have linked to slower epithelial mesothelioma progression

Mesothelioma specialists are continuing to study how an individual’s biological gender may contribute to their risk of developing mesothelioma.

Know Your Risks for Developing Mesothelioma

There are many potential risk factors that may contribute to the development of mesothelioma, but few of them have been confirmed. Asbestos exposure is, overwhelmingly, the main risk factor for developing this deadly disease.

If you or a loved one have been diagnosed with mesothelioma, you likely have questions about how this could have happened. You are not alone.

The Mesothelioma Justice Network is dedicated to helping you get answers about your mesothelioma diagnosis. Contact us today.

Mesothelioma Support Team
Reviewed by:Dr. Mark Levin

Certified Oncologist and Hematologist

  • Fact-Checked
  • Editor

Mark Levin, MD has nearly 30 years of experience in academic and community hematology and oncology. In addition to serving as Chief or Director at four different teaching institutions throughout his life, he is also still a practicing clinician, has taught and designed formal education programs, and has authored numerous publications in various fields related to hematology and oncology.

Dr. Mark Levin is an independently paid medical reviewer.

Stephanie KiddWritten by:

Editor-in-Chief

Stephanie Kidd grew up in a family of civil servants, blue-collar workers, and medical caregivers. Upon graduating Summa Cum Laude from Stetson University, she began her career specializing in worker safety regulations and communications. Now, a proud member of the American Medical Writers Association (AMWA) and Editor-in-Chief of the Mesothelioma Justice Network, Stephanie serves as a voice for mesothelioma victims and their families.

View 7 Sources
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  2. American Cancer Society. “ACS Guidelines on Nutrition and Physical Activity for Cancer Prevention.” Retrieved from https://www.cancer.org/healthy/eat-healthy-get-active/acs-guidelines-nutrition-physical-activity-cancer-prevention.html. Accessed on January 16, 2018.
  3. American Cancer Society. “Diet and Physical Activity: What’s the Cancer Connection?” Retrieved from https://www.cancer.org/cancer/cancer-causes/diet-physical-activity/diet-and-physical-activity.html. Accessed on January 16, 2018.
  4. U.S. Geological Survey. “Asbestos: Geology, Mineralogy, Mining, and Uses.” Retrieved from https://pubs.usgs.gov/of/2002/of02-149/of02-149.pdf. Accessed on January 16, 2018.
  5. U.S. Geological Survey. “Zeolites Statistics and Information.” Retrieved from https://minerals.usgs.gov/minerals/pubs/commodity/zeolites/. Accessed on January 16, 2018.
  6. Shavelle, R., Vavra-Musser, K., Lee, J., & Brooks, J. (2017). Life Expectancy in Pleural and Peritoneal Mesothelioma. Lung cancer international, 2017, 2782590. Retrieved April 2, 2020, from https://doi.org/10.1155/2017/2782590
  7. National Association for Rare Diseases. (n.d.). Mesothelioma. Retrieved April 2, 2020, from https://rarediseases.org/rare-diseases/mesothelioma/
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