Mesothelioma Related Clinical Trials:
Early Diagnosis of Mesothelioma and Lung Cancer Following Asbestos Exposure Using Low-Dose Computed Tomography


    - General Info     - Purpose     - Eligibility     - Contacts & Locations     - Additional Information

Status: Recruiting
Sponsors and Collaborators: University Health Network, Toronto
Information provided by: University Health Network, Toronto
Government Identifier: NCT00188890

Condition: Lung Cancer, Mesothelioma
Intervention:

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Purpose:


Occupational exposure to asbestos is known increase the risk of developing cancer of the lungs (bronchogenic carcinoma) or of the pleura (mesothelioma). Symptoms are subtle and non-specific, diagnosis is often late and the prognosis consequently is dismal. Currently there is no accepted non-invasive tool for the early diagnosis of mesothelioma or lung cancer in asbestos-exposed subjects. In the last decade, low-dose computed tomography (LDCT) has been successfully developed and validated for the early diagnosis of lung cancer in high-risk smokers. Malignant mesothelioma might, in an early stage, resemble a benign pleural plaque, which is a common finding after asbestos exposure. We target to develop low-dose CT as a tool to serially image the pleural plaques, quantify their individual and overall volume, compute the growth rate with time, and, as such, identify the presence of mesothelioma early, before symptoms occur.

Study Type: Observational
Study Design: Case Control, Other
Official Title: Early Diagnosis of Mesothelioma and Lung Cancer Following Asbestos Exposure Using Low-Dose Computed Tomography

Further study details as provided by University Health Network, Toronto:

Biospecimen Retention: None Retained

Biospecimen Description:

Estimated Enrollment: 1000
Study Start Date: March 2005
Estimated Study Completion Date: March 2010

Groups/Cohorts

prior exposure to asbestos

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Eligibility:

Ages Eligible for Study: 30 Years to 85 Years
Genders Eligible for Study: Both
Accepts Healthy Volunteers: Yes
Sampling Method: Non-Probability Sample

Study Population

prior exposure to asbestos and or documented pleural plaques


Criteria

Inclusion Criteria:

prior asbestos exposure at least 20 years ago and/or documented pleural plaques (chest x-ray evidence)

Resident of Ontario, Canada

Exclusion Criteria:

prior cancer (except non-melanotic skin cancer)

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Contacts and Locations:

Please refer to this study by its ClinicalTrials.gov identifier: NCT00188890

Contacts
Contact: Demetris Patsios, MD Tel: (416) 603-5800 ext 2583 demetris.patsios@uhn.on.ca
Contact: Brenda O'Sullivan 416-340-4800 ext 5686 Brenda.O'Sullivan@uhn.on.ca
Locations
Canada, Ontario
Princess Margaret Hospital Recruiting
Toronto, Ontario, Canada
Contact: Demetris Patsios, MD Tel: (416) 603-5800 ext 2583 demetris.patsios@uhn.on.ca
Contact: Brenda O'Sullivan, MD 416-340-4800 ext 5686 brenda.o'sullivan@uhn.on.ca

Sponsors and Collaborators
University Health Network, Toronto

Investigators
Principal Investigator: Demetris Patsios, MD University Health Network, Toronto
Principal Investigator: Michael Johnston, MD University Health Network, Toronto

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Additional Information:

Study ID Numbers: Asbestos Screening Study
First Received: September 12, 2005
Last Updated: October 31, 2007
ClinicalTrials.gov Identifier: NCT00188890
Health Authority: Canada: Health Canada

Keywords provided by University Health Network, Toronto:
Lung Cancer
Mesothelioma
Asbestos
Screening
Early Diagnosis

Study placed in the following topic categories:
Thoracic Neoplasms
Lung Neoplasms
Lung Diseases
Mesothelioma
Adenoma
Neoplasms, Glandular and Epithelial

Additional relevant MeSH terms:
Respiratory Tract Neoplasms
Neoplasms
Neoplasms by Site
Neoplasms by Histologic Type
Mesothelioma
Respiratory Tract Diseases
Neoplasms, Mesothelial

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