Mesothelioma Related Clinical Trials:
Radiofrequency Ablation of Pulmonary Malignancy

Article Tools:

In Page Navigation: - General Info - Purpose - Eligibility - Contacts & Locations - Additional Information

   

Status: Active
Sponsors and Collaborators: Jonsson Comprehensive Cancer Center; National Cancer Institute (NCI)
Information provided by: National Cancer Institute (NCI)
Government Identifier: NCT00024076

Condition: Lung Cancer; Malignant Mesothelioma; Metastatic Cancer; Thymoma and Thymic Carcinoma
Intervention: Procedure: radiofrequency ablation

    - Return To Top

Purpose:


RATIONALE: Radiofrequency ablation uses high-frequency electric current to kill tumor cells. CT-guided radiofrequency ablation may be effective treatment for lung cancer.

PURPOSE: Phase II trial to study the effectiveness of radiofrequency ablation in treating patients who have refractory or advanced lung cancer.

Study Type:   Interventional
Study Design:   Treatment
Official Title:   Radiofrequency Ablation of Pulmonary Malignancy

Further study details as provided by National Cancer Institute (NCI):

Study Start Date:   July 2001

Detailed Description:

OBJECTIVES:

  • Determine the safety and toxicity of radiofrequency ablation in patients with refractory or advanced pulmonary malignancies.
  • Determine the efficacy of this treatment, in terms of local control, in these patients.
  • Determine whether CT scan is a reasonable imaging assessment tool for treatment delivery and follow-up in these patients.

OUTLINE: Patients undergo percutaneous CT-guided radiofrequency ablation directly to the tumor over 2 hours.

Patients are followed at 1, 3, 6, and 12 months.

PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study.

    - Return To Top

Eligibility:

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Criteria

DISEASE CHARACTERISTICS:

  • Diagnosis of a primary or secondary intrathoracic malignancy

    • Any cell type or origin
    • Involving the intrapulmonary, mediastinal, or pleural/chest wall
    • Inoperable primary or metastatic cancer to the lung
  • Refractory to or not amenable to conventional therapy (e.g., surgery, chemotherapy, or radiotherapy)
  • Single or multiple lesions that are non-contiguous with vital structures or organs such as:
    • Trachea
    • Heart
    • Aorta
    • Great vessels
    • Esophagus
  • Less than 5 cm in largest dimension
  • Accessible via percutaneous transthoracic route

PATIENT CHARACTERISTICS:

Age:

  • Not specified

Performance status:

  • Not specified

Life expectancy:

  • Not specified

Hematopoietic:

  • Not specified

Hepatic:

  • Coagulation profile normal

Renal:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics

    - Return To Top

Contacts and Locations:

Please refer to this study by its ClinicalTrials.gov identifier: NCT00024076
Locations
United States, California
Jonsson Comprehensive Cancer Center, UCLA    
      Los Angeles, California, United States, 90095-1781

Sponsors and Collaborators
Jonsson Comprehensive Cancer Center
National Cancer Institute (NCI)

Investigators
Study Chair:     Robert D. Suh, MD     Jonsson Comprehensive Cancer Center    

    - Return To Top

Additional Information:

Study ID Numbers:   CDR0000068889, UCLA-9908024, NCI-G01-2011
First Received:   September 13, 2001
Last Updated:   November 16, 2007
ClinicalTrials.gov Identifier:   NCT00024076
Health Authority:   United States: Federal Government

Keywords provided by National Cancer Institute (NCI):
recurrent non-small cell lung cancer  
recurrent small cell lung cancer  
recurrent malignant mesothelioma  
recurrent thymoma and thymic carcinoma  
stage IIIB non-small cell lung cancer
stage IV non-small cell lung cancer
pulmonary carcinoid tumor
lung metastases

Study placed in the following topic categories:
Thoracic Neoplasms
Non-small cell lung cancer
Recurrence
Carcinoma
Carcinoid tumor
Carcinoma, Small Cell
Signs and Symptoms
Pathologic Processes
Lung Neoplasms
Lung Diseases
Thymoma
Thymus Neoplasms
Neoplasm Metastasis
Mesothelioma
Carcinoid Tumor
Carcinoma, Non-Small-Cell Lung
Adenoma
Neoplasms, Glandular and Epithelial

Additional relevant MeSH terms:
Respiratory Tract Neoplasms
Neoplastic Processes
Neoplasms
Neoplasms by Site
Neoplasms by Histologic Type
Mesothelioma
Respiratory Tract Diseases
Neoplasms, Mesothelial
Neoplasms, Complex and Mixed
Pathological Conditions, Signs and Symptoms

    - Return To Top

Free case consultation

If you or a loved one has been diagnosed with mesothelioma or another asbestos-related disease, contact us using the form below to speak with a mesothelioma consultant, free of charge.